Allopurinol CAS NO.315-30-0

We can Supply Allopurinol IP,USP,BP Allopurinol is a drug used primarily to treathyperuricemia(excessuric acidinblood plasma) and it…

We can Supply Allopurinol IP,USP,BP Allopurinol  is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout UsesGout and hyperuricemia Subsequently the uric acid lowering capacity of allopurinol was noted, and the drug went on to be developed for its more famous use to treat hyperuricemia (excess uric acid in blood plasma) and its complications Tumor lysis syndrome Allopurinol was also commonly used in chemotherapeutic treatments to treat 'tumor lysis syndrome' (as these regimes can rapidly produce severe acute hyperuricemia) although it has gradually been replaced by urate oxidase therapyThiopurine co-therapyAllopurinol can cause severe pancytopenia if given with full-dose mercaptopurine or its pro-drug azathioprine, due to the inhibition of xanthine oxidase that metabolizes mercaptopurine. For this reason, allopurinol has usually been contraindicated for thiopurine therapy.Reperfusion injuryOther established indications for allopurinol therapy include ischemic reperfusion injury, kidney stones with a uric acid component (uric acid nephrolithiasis), and protozoal infections (Leishmaniasis).EpilepsyAllopurinol is used as an add-on drug for refractory epilepsy, because it is an adenosine agonist, which inhibits glutamine release from excitatory neurons, but does not change the plasma concentration of other epilepsy drugs.Blood pressureAllopurinol can lower blood pressure in mild hypertensionRenal disease, Heart failure and AnginaAllopurinol can be used in patients with poor kidney function, but it may also help them. A study of allopurinol use in patients with chronic kidney disease suggested that "Allopurinol decreases C-reactive protein and slows down the progression of renal disease in patients with chronic kidney disease. In addition, allopurinol reduces cardiovascular and hospitalization risk in these subjects